I created this map using the in-game map from SR2 and official concept art.  It highlights locations visited in Defiance, (all of which were familiar from previous games, with the exception of the Vampire Citadel) and notes other landmarks of interest within this region of Nosgoth, that existed during the time periods in which Defiance was set.

The full extent of the subterranean ruins that the Elder inhabited is presently unknown, but the games indicated that they run as far east as the Sarafan Stronghold, as far west as the Ancient Vampire Citadel, as far south as the Ziegsturhl cemetery, and as far north as Termogent Forest during this 500-year period in Nosgoth’s history.